Category:MIHV
From Holoprosencephaly
MIDDLE INTERHEMISPHERIC VARIANT OF HOLOPROSENCEPHALY
MIHV of Holoprosencephaly has neuroimaging features that are different from classic HPE. Unlike classic HPE where the most severely nonseparated region of the hemispheres is the basal forebrain, in MIH the posterior frontal and parietal lobes are affected.
The anterior portions of the frontal lobes and the occipital lobes are well separated in MIH. The genu and splenium of the corpus callosum appear normally formed, but the callosal body is absent. The hypothalamus and lentiform nuclei appear normally separated, but the caudate nuclei and thalami are incompletely separated in many cases.
Usually, the sylvian fissures are oriented nearly vertically and are abnormally connected across the midline over the vertex of the brain. Approximately two thirds of MIH patients have either subcortical heterotopic gray matter or cortical dysplasia.
Click here to read about: New Diagnosis of Holoprosencephaly
Click here to read what specialists have to say about caring for children with Holoprosencephaly: Doctor Q&A
Resources
http://hpe.stanford.edu/about/
