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Category:Lobar

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LOBAR HOLOPROSENCEPHALY

Lobar Holoprosencephaly is the least severe of the major types of HPE. The cerebral hemispheres are reasonably well separated and there is some frontal horn development noted in the lateral ventricles. The ventricles still appear dysmorphic due to absence of the septum pellucidum.

Often the posterior half of the corpus callosum is formed. The third ventricle is usually well formed as well. Varying degrees of basal ganglia and thalamic fusion may be seen, as may a dorsal cyst. Midline craniofacial defects are often absent or mild, sometimes restricted to hypotelorism, but may include cleft lip and palate, as well as other abnormalities.


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